Naguib, Fardos N. M.: search on Z-Library

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1

Tight binding inhibitors—IX: Kinetic parameters of dihydrofolate reductase inhibited by methotrexate, an example of equilibrium study

Sungman Cha, Suzie Y.R. Kim, Susan G. Kornstein, Phillip W. Kantoff, Kyung Hwan Kim, Fardos N.M. Naguib

Journal:

Biochemical Pharmacology

Year:

1981

Language:

english

File:

PDF, 792 KB

english, 1981

2

Effects of N,N-dimethylformamide and sodium butyrate on enzymes of pyrimidine metabolism in cultured human tumor cells

Fardos N.M. Naguib, John G. Niedzwicki, Max H. Iltzsch, Michael C. Wiemann, Mahmoud H. el Kouni, Sungman Cha

Journal:

Leukemia Research

Year:

1987

Language:

english

File:

PDF, 638 KB

english, 1987

3

SYNTHESIS OF CARBOCYCLIC OROTIDINE ANALOGS AS POTENTIAL OROTIDINE DECARBOXYLASE INHIBITORS

Song, Gyu, Naguib, Fardos, el Kouni, Mahmoud, Chu, Chung

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2001

Language:

english

File:

PDF, 173 KB

english, 2001

4

5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration: Implications for chemotherapy

Osama M. Ashour, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.24 MB

english, 1996

5

Structure–activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase

Young Ah Kim, Ravindra K. Rawal, Jakyung Yoo, Ashoke Sharon, Ashok K. Jha, Chung K. Chu, Reem H. Rais, Omar N. Al Safarjalani, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

6

Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine

Naguib, Fardos N.M., Rais, Reem H., Al Safarjalani, Omar N., el Kouni, Mahmoud H.

Journal:

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 614 KB

english, 2015

7

ChemInform Abstract: Synthesis of Carbocyclic Orotidine Analogues as Potential Orotidine Decarboxylase Inhibitors.

Gyu Y. Song, Fardos N. M. Naguib, Mahmoud H. el Kouni, Chung K. Chu

Journal:

Year:

2002

File:

PDF, 32 KB

2002

8

Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Omar N. Al Safarjalani, Xiao-Jian Zhou, Fardos N. Naguib, Naganna M. Goudgaon, Raymond F. Schinazi, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

9

Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy

Omar N. Safarjalani, Xiao-Jian Zhou, Fardos N. Naguib, Junxing Shi, Raymond F. Schinazi, Mahmoud H. Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2001

Language:

english

File:

PDF, 182 KB

english, 2001

10

7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

Omar N. Al Safarjalani, Reem H. Rais, Young Ah Kim, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 388 KB

english, 2008

11

ChemInform Abstract: Uridine Phosphorylase Inhibitors: Chemical Modification of Benzyloxybenzyl-barbituric Acid and Its Effects on UrdPase Inhibition.

David J. Guerin, Daniel Mazeas, Manoj S. Musale, Fardos N. M. Naguib, Omar N. Al Safarjalani, Mahmoud H. el Kouni, Raymond P. Panzica

Journal:

Year:

1999

File:

PDF, 29 KB

1999

12

Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine

Osama M Ashour, Fardos N.M Naguib, Raymond P Panzica, Omar N Al Safarjalani, Mahmoud H el Kouni

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

13

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Fardos N.M. Naguib, Max H. Iltzsch, Mustapha M. el Kouni, Raymond P. Panzica, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

14

Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase

Goudgaon, Naganna M., Naguib, Fardos N. M., el Kouni, Mahmoud H., Schinazi, Raymond F.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 735 KB

english, 1993

15

Nucleoside auxotrophy inDrosophila: An autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides

Fardos N. M. Naguib, David Nash

Journal:

Molecular Genetics and Genomics

Year:

1976

Language:

english

File:

PDF, 718 KB

english, 1976

16

Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

Omar N. Al Safarjalani, Reem Rais, Junxing Shi, Raymond F. Schinazi, Fardos N. M. Naguib, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 227 KB

english, 2006

17

Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil: Possible relevance to regional chemotherapy

George C. Daher, Fardos N.M. Naguib, Mahmoud H. El Kouni, Ruiwen Zhano, Seng J. Soong, Robert B. Diasio

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 844 KB

english, 1991

18

Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii

Mahmoud H. el Kouni, Fardos N.M. Naguib, Raymond P. Panzica, Brian A. Otter, Shih-Hsi Chu, Gilles Gosselin, Chung K. Chu, Raymond F. Schinazi, Y.Fulmer Shealy, Naganna Goudgaon, Alexander A. Ozerov, T

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.56 MB

english, 1996

19

Uridine phosphorylase inhibitors: Chemical modification of benzyloxybenzyl-barbituric acid and its effects on UrdPase inhibition

David J. Guerin, Daniel Mazeas, Manoj S. Musale, Fardos N.M. Naguib, Omar N. Al Safarjalani, Mahmoud H. el Kouni, Raymond P. Panzica

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

20

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity

Al Safarjalani, Omar N., Rais, Reem, Naguib, Fardos N. M., el Kouni, Mahmoud H.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 202 KB

english, 2012

21

Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice

Mahmoud H. el Kouni, Fardos N.M. Naguib, Park Kyung Sun, Cha Sungman, James W. Darnowskl, Seng-Jaw Soong

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 766 KB

english, 1990

22

Nucleoside kinases in adult Schistosoma mansoni: Phosphorylation of pyrimidine nucleosides

Naguib, Fardos N.M., el Kouni, Mahmoud H.

Journal:

Molecular and Biochemical Parasitology

Year:

2014

Language:

english

File:

PDF, 288 KB

english, 2014

23

Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities

Omar N. Al Safarjalani, Reem H. Rais, Young Ah Kim, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 251 KB

english, 2010

24

6-Benzylthioinosine analogues: Promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es)

Amol Gupte, John K. Buolamwini, Vikas Yadav, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 202 KB

english, 2005

25

Circadian rhythm of orotate phosphoribosyltransferase, pyrimidine nucleoside phosphorylases and dihydrouracil dehydrogenase in mouse liver: Possible relevance to chemotherapy with 5-fluoropyrimidines

Fardos N.M. Naguib, Soong Seng-Jaw, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 981 KB

english, 1993

26

6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: Activities and selective toxicities

Reem H. Rais, Omar N. Al Safarjalani, Vikas Yadav, Vincenzo Guarcello, Marion Kirk, Chung K. Chu, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 249 KB

english, 2005

27

Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2′-deoxyuridine against murine colon tumor C26–10

Osama M Ashour, Fardos N.M Naguib, Naganna M Goudgaon, Raymond F Schinazi, Mahmoud H el Kouni

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

28

Synthesis, Biological Activity and Molecular Modeling of 6-Benzylthioinosine Analogues as Subversive Substrates of Toxoplasma g ondii Adenosine Kinase

Yadav, Vikas, Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Guarcello, Vincenzo, Naguib, Fardos N. M.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 449 KB

english, 2004

29

Synthesis of a new class of uridine phosphorylase inhibitors

Diane L. Levesque, Eng-Chi Wang, Dau-Chang Wei, Cherng-Chyi Tzeng, Raymond P. Panzica, Fardos N. M. Naguib, Mahmoud H. El Kouni

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 512 KB

1993

30

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents

Young Ah Kim, Ashoke Sharon, Chung K. Chu, Reem H. Rais, Omar N. Al Safarjalani, Fardos N.M. Naguib, Mahmoud H. el Kouni

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 1.89 MB

english, 2007

31

Enzymes of pyrimidine salvage pathways in intraerythrocytic Plasmodium falciparum

Naguib, Fardos N.M., Wilson, Craig M., el Kouni, Mahmoud H.

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2018

Language:

english

File:

PDF, 531 KB

english, 2018

32

Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy

Osama M. Ashour, Fardos N. M. Naguib, Naganna M. Goudgaon, Raymond F. Schinazi, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 106 KB

english, 2000

33

Synthesis And Biological Activity Op Hydpdxymetflyl Analogs op 5-Benzylacyclouridine and 5-Benzyloxybenzylacycloaridine

Chu, Shih Hsi, Chen, Zhi Hao, Rowe, Elizabeth C., Naguib, Fardos N. M., el Kouni, Hahmoud H., Chu, Ming Y.

Journal:

Nucleosides and Nucleotides

Year:

1984

Language:

english

File:

PDF, 548 KB

english, 1984

34

Suppression of thymidine phosphorylase expression by promoter methylation in human cancer cells lacking enzyme activity

Vincenzo Guarcello, Carmelo Blanquicett, Fardos N. M. Naguib, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 392 KB

english, 2008

35

Structure-activity relationship of ligands of dihydrouracil dehydrogenase from mouse liver

Fardos N.M. Naguib, Mahmoud H. El Kouni, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 984 KB

english, 1989

36

Pyrimidine salvage pathways in adult Schistosoma mansoni

Mahmoud H. El Kouni, Fardos N.M. Naguib

Journal:

International Journal for Parasitology

Year:

1990

Language:

english

File:

PDF, 1002 KB

english, 1990

37

Structure−Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine Kinase

Kim, Young Ah, Sharon, Ashoke, Chu, Chung K., Rais, Reem H., Al Safarjalani, Omar N., Naguib, Fardos N. M., el Kouni, Mahmoud H.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 640 KB

english, 2008

38

Synthesis of 5-Benzyl and 5-Benzyloxybenzyl 2,2′-Anhydrouridines and Related Nucleoside Analogs as Inhibitors of Uridine Phosphorylase

Chu, Shih Hsi, Weng, Zum Yao, Chen, Zhi Hao, Rowe, Elizabeth C., Chu, Edward, Naguib, Fardos N. M., el Kouni, Mahmoud H., Cha, Sungman, Chu, Ming Y.

Journal:

Nucleosides and Nucleotides

Year:

1988

Language:

english

File:

PDF, 548 KB

english, 1988

39

New analogues of benzylacyclouridines, specific and potent inhibitors of uridine phosphorylase from human and mouse livers

Fardos N.M. Naguib, Mahmoud H. el Kouni, Shih Hsi Chu, Sungman Cha

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 699 KB

english, 1987

40

Two Drosophila melanogaster Mutations Block Successive Steps of de novo Purine Synthesis

Steven Henikoff, David Nash, Robert Hards, John Bleskan, J. F. Woolford, Fardos Naguib and David Patterson

Journal:

Proceedings of the National Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 982 KB

english, 1986

41

Triazine Acyclonucleosides: Potential Inhibitors of Pyrimidine Enzymes 1

Purkayastha, Subhasish, Lazrek, Bihi H., Panzica, Raymond P., Naguib, Fardos N. M., el Kouni, Mahmoud H.

Journal:

Nucleosides and Nucleotides

Year:

1989

Language:

english

File:

PDF, 268 KB

english, 1989

42

5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens

Omar N. Al Safarjalani, Xiao-Jian Zhou, Reem H. Rais, Junxing Shi, Raymond F. Schinazi, Fardos N. M. Naguib, Mahmoud H. el Kouni

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 427 KB

english, 2005

43

Insertional tagging of at least two loci associated with resistance to adenine arabinoside in Toxoplasma gondii, and cloning of the adenosine kinase locus

William J. Sullivan Jr., Chi-Wu Chiang, Craig M. Wilson, Fardos N.M. Naguib, Mahmoud H. el Kouni, Robert G.K. Donald, David S. Roos

Journal:

Molecular and Biochemical Parasitology

Year:

1999

Language:

english

File:

PDF, 586 KB

english, 1999

44

5-Benzylbarbituric acid derivatives, potent and specific inhibitors of uridine phosphorylase

Fardos N.M. Naguib, Diane L. Levesque, Eng-Chi Wang, Raymond P. Panzica, Mahmoud H. El Kouni

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.31 MB

english, 1993

45

Synthesis of [4-(hydroxy)tetrahydrofuran-2-yl]nucleosides as a novel class of uridine phosphorylase inhibitors

Te-Fang Yang, Lakshmi P. Kotra, Quincy Teng, Fardos N.M. Naguib, Jean-Pierre Sommadossi, Mahmoud el Kouni, Chung K. Chu

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 233 KB

english, 1995

46

5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase

Mahmoud H el Kouni, Naganna M Goudgaon, Mohammad Rafeeq, Omar N Al Safarjalani, Raymond F Schinazi, Fardos N.M Naguib

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 273 KB

english, 2000

47

Isolation and characterization of deficiencies exposing the rudimentary locus of Drosophila melanogaster

Naguib, Fardos N. M., Jarry, Bruno

Journal:

Genetics Research

Year:

1981

Language:

english

File:

PDF, 471 KB

english, 1981

48

Metabolism and Selective Toxicity of 6-Nitrobenzylthioinosine in Toxoplasma gondii

el Kouni, Mahmoud H., Guarcello, Vincenzo, Al Safarjalani, Omar N., Naguib, Fardos N. M.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1999

File:

PDF, 100 KB

1999

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